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To HLA activates endothelial exocytosis, releasing VWF and externalizing P-selectin, which

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To HLA activates endothelial exocytosis, releasing VWF and externalizing P-selectin, which lead to platelet aggregation and leukocyte infiltration. Discussion The major finding of this study is that antibody to HLA activates endothelial exocytosis in vitro and in vivo. These data suggest that one mechanism for antibody injury to transplanted organs is through antibody-triggering endothelial cell e
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Mi1304 www.pnas.org cgi doi 10.1073 pnas.crovessels (Fig. 7E). Antibody

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Mi1304 www.pnas.org cgi doi 10.1073 pnas.crovessels (Fig. 7E). Antibody to HLA also increases leukocyte infiltration into human skin grafts (Fig. 7 F and G). Some leukocytes appear to have infiltrated into the tissue after 6 h. These data support a model in which antibody to HLA triggers the externalization of P-selectin, thus contributing to an increase in inflammation. Furthermore, some platelet
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Antibody may also contribute to endothelial degranulation and neutrophil adherence after

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Antibody may also contribute to endothelial degranulation and neutrophil adherence after 6 h, such as the synthesis of new proteins. However, these data suggest that antibody to human HLA could activate endothelial cells and inflammation in humans independently of the complement system.Implications for Diseases: Graft Rejection. Pathological changes in(Sigma ldrich). To measure apoptosis, HAEC wer
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Afts of mice treated with antibody to HLA (Right). Arrows point

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Afts of mice treated with antibody to HLA (Right). Arrows point toward capillaries. Some capillaries (Right) contain neutrophils staining purple as well as platelets staining brown.trigger specific intracellular signal transduction cascades, including NF- B, tyrosine kinases, and generation of inositol phosphate (21). IP3 in turn activates the IP3 receptor to release internal stores of calcium. We
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Up in Arms About Phone Lookup? Whispered Phone Lookup Secrets Most providers provide call packages that enable calls at no cost at particular times of the day. Besides the countless websites available at the click of a button, the world wide web also holds the secret to gathering information in ways that lots of folks wouldn't have believed mere years back. It is going
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A project is a temporary endeavor designed to produce a unique product, service or result with a defined beginning and end (usually time-constrained, and often constrained by funding or staffing) undertaken to meet unique goals and objectives, typically to bring about beneficial change or added value.The temporary nature of projects stands in contrast with business as usual (or operations),which a
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Ion fromPNAS January 23, 2007 vol. 104 no. 4IMMUNOLOGYendothelial cells into the lumen and

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Ion fromPNAS January 23, 2007 vol. 104 no. 4IMMUNOLOGYendothelial cells into the lumen and into the subendothelial space of medium-sized vessels (Fig. 7). Furthermore, small vessels in human skin grafts appeared plugged with VWF after antibody administration (Fig. 7). Finally, antibody treatment increases neutrophil infiltration into human skin grafts (Fig. 7). Endothelial degranulation can be obs
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Ed and sections were stained. (A) Photomicrographs of staining for VWF

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Ed and sections were stained. (A) Photomicrographs of staining for VWF after 1 h. (B) Quantitation or VWF release after 1 h (n 8 SD; *, P 0.04). (C) Photomicrographs of staining for MPO in dermal vessels after 1 h. Clusters of cells in small vessels stain for MPO in antibody-treated grafts. (D) Quantitation of MPO-positive cells after 1 h (n 8 SD; *, P 0.03). (E) Quantitation of VWF release after
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